P53gene相关论文
As DNA is often used as an intelligent building block,increasing attention has been paid for the specific purpose toward......
A polyethylenimine derivative-based nanocarrier for the highly efficient delivery of p53 gene to inh
The p53 gene has been widely investigated and considered to be an effective tumor suppressor in cancer gene therapy [1].......
目的 探讨p53基因在病理性瘢痕中的表达及意义.方法 选用手术切除的病理性瘢痕30例,作为实验组,根据临床表现及病理将其进行分组,......
DNA origami directed in-situ combination of chemotherapy and gene therapy with enhanced antitumor ef
Malignant tumor is one of the most serious diseases that affect human health.As patients with long-term chemotherapy,mul......
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目的探讨中药通痹灵在类风湿关节炎（RA）发病中对软骨细胞凋亡及其基因p53、Bcl-2调控的作用机制。方法采用大鼠CIA模型，分别予通痹灵......
Efficacy of Recombinant Adenoviral Human p53Gene in Treatment of Malignant Pleural or Peritoneal Eff
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Exogenous acid fibroblast growth factor inhibits ischemia-reperfusion-induced damage in intestinal e
AIM: To detect the effect of acid fibroblast growth factor (aFGF) on P53 and P21WAF-1 expression in rat intestine after ......
Transcatheter arterial chemoembolization (TACE) has become the standard treatment for unresectable hepatocellular carcin......
Homozygosity for Pro of p53 Arg72Pro as a potential risk factor for hepatocellular carcinoma in Chin
AIM: Codon 72 exon 4 polymorphism (Arg72Pro) of the p53 gene has been implicated in cancer risk. Our objective was to in......
A p53 genetic polymorphism of gastric cancer: Difference between early gastric cancer and advanced g
AIM: To investigate the role of the polymorphism of p53 codon 72 in early gastric cancer (EGC) and advanced gastric canc......
Hepatocellular carcinoma(HCC)is one of the 10 most common cancers worldwide.There is no ideal treatment for HCC yet and ......
p53-expressing conditionally replicative adenovirus CNHK500-p53 against hepatocellular carcinomain v
AIM: To develop a conditionally replicative gene-viral vector system called CNHK500-p53, which contains dual promoters w......
Objective To investigate the changes of the cell cycle regulators ATM, Chk2 and p53 and cell cycle arrest in HeLa cells ......
目的探讨具有不同潜在转移能力的黑色素瘤细胞恶性表型的演进及其侵袭转移的机制。方法采用细胞培养，p53蛋白免疫组化染色，PCR-SSCP......
Objective: To study apoptosis induced by radiation in two nasopharyngeal carcinoma (NPC) cell lines, CNE and CNE-2. Meth......
Apoptosisnowhasbecomeahotspotofcancerresearchbecauseitisregardedthatapoptosishasrelationshipwithcarcinogenesis,developme......
应用ＰＣＲ－ＳＳＣＰ结合ＰＣＲ产物直接银染测序技术对２４例大肠癌Ｐ５３基因第５￣７外显进行点突变的研究。结果检出５例（２６．７％）阳性，均为错义突变；其中３例为碱基ＧＣ到ＡＴ的转换，１例为ＧＣ到ＴＡ的......
目的 观察外源野生型ｐ５３基因在肝癌基因治疗方面的可行性。方法 将载有人野生型ｐ５３－ｃＤＮＡ的真核表达质粒ｐ５３－ｐｃＤＮＡ３，用阳离子脂质体介导转染人肝癌细胞系......
目的 探讨P53基因表达在子宫内膜癌发生、发展中的作用。方法 用原位杂交法、免疫组化法及苏木素-HE染色，分别测定37例子宫内膜癌病......
了解人卵巢癌中Ｐ５３基因突变的特点及其与临床分期的关系。...
目的：对瘢痕疙瘩p53基因检测试剂盒进行临床实验,评价此试剂盒的准确度和有效性。方法：运用聚合酶链反应-反向斑点杂交、DNA直接测序......
目的观察７６例乳腺病变组织中ｎｍ２３－Ｈ１及突变型Ｐ＾５３基因的表达情况，分析其与乳腺癌生物学行为及淋巴结转移的关系。方法 应用ＳＰ免疫组织化学方法检测......
目的：探讨转染野生型 p53（ wt-p53）和突变型 p53（ mt-p53）基因对人肺腺癌细胞株 GLC-82裸鼠移植瘤生长的影响。方法：采用脂质体介导法，分......
背景与目的；实验研究证明p53和血管内皮生长因子（vascular endothelial growth factor,VEGF)协同表达在肿瘤血管生成中有重要作用。......
背景与目的：幽门螺杆菌（Helicobacter pylori,Hp)是确定的胃癌致癌因子，但其致癌的确切机制仍不清楚，p53,p21^WAF1,p16为主要的细胞周......
目的：检测急性白血病细胞内ｐ５３基因表达情况。方法：＾３Ｈ－ｄＡＴＰ标记基因探针的斑点杂交。结果：急性淋巴细胞白血病（ＡＬＬ）表达ｐ５３ＲＮＡ水平与正常对照类似，急性非淋巴......
目的探讨肺活检和支气管肺泡灌洗液(BALF)标本p53、K-ras和p16基因检测对肺癌诊断的意义.方法应用多聚合酶链反应(PCR)-单链构象多......
目的:检测头颈部鳞癌患者p53基因突变、mdm2基因扩增的状况,了解其与头颈部鳞癌患者的性别、鳞癌分级、淋巴结转移等的相关性及两......
目的：探讨p53在异丙肾上腺素（Iso）所致心肌纤维化大鼠心肌组织中的表达及意义,阐明其在心肌纤维化中的作用。方法：25只大鼠随机分为5组......
用聚合酶链反应－限制性片段长度多态性方法分析了原发性肝癌组织中Ｐ＾５３基因第２４９密码子的点突变，突变率为４８．４％，结果表明Ｐ＾５３基因的突变可能与环境致癌......
